GrippeEspagneV1, Main, Exploration, bibRecord, 000035

Impact of Rapid On-demand Molecular Diagnosis of Pediatric Seasonal Influenza on Laboratory Workflow and Testing Costs: A Retrospective Study.

Identifieur interne : 000035 ( Main/Exploration ); précédent : 000034; suivant : 000036

Impact of Rapid On-demand Molecular Diagnosis of Pediatric Seasonal Influenza on Laboratory Workflow and Testing Costs: A Retrospective Study.

Auteurs : Pedro Brotons [Espagne] ; Maria-Mercedes Nogueras [Espagne] ; Ana Valls [Espagne] ; Amparo Larrauri [Espagne] ; Angela Dominguez [Espagne] ; Cristian Launes [Espagne] ; Carlos Luaces-Cubells [Espagne] ; Carmen Mu Oz-Almagro [Espagne]

Source :

The Pediatric infectious disease journal [ 1532-0987 ] ; 2019.

RBID : pubmed:31117115

Descripteurs français

KwdFr :
- Coûts et analyse des coûts (MeSH), Dossiers médicaux électroniques (MeSH), Espagne (MeSH), Flux de travaux (MeSH), Grippe humaine (diagnostic), Humains (MeSH), Sensibilité et spécificité (MeSH), Systèmes automatisés lit malade (normes), Systèmes automatisés lit malade (économie), Techniques de diagnostic moléculaire (normes), Techniques de diagnostic moléculaire (économie), Techniques de laboratoire clinique (économie), Trousses de réactifs pour diagnostic (normes), Trousses de réactifs pour diagnostic (économie), Virus de la grippe A (isolement et purification), Virus influenza B (isolement et purification), Études rétrospectives (MeSH).
MESH :
- diagnostic : Grippe humaine.
- isolement et purification : Virus de la grippe A, Virus influenza B.
- normes : Systèmes automatisés lit malade, Techniques de diagnostic moléculaire, Trousses de réactifs pour diagnostic.
- économie : Systèmes automatisés lit malade, Techniques de diagnostic moléculaire, Techniques de laboratoire clinique, Trousses de réactifs pour diagnostic.
- Coûts et analyse des coûts, Dossiers médicaux électroniques, Espagne, Flux de travaux, Humains, Sensibilité et spécificité, Études rétrospectives.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- Clinical Laboratory Techniques (economics), Costs and Cost Analysis (MeSH), Electronic Health Records (MeSH), Humans (MeSH), Influenza A virus (isolation & purification), Influenza B virus (isolation & purification), Influenza, Human (diagnosis), Molecular Diagnostic Techniques (economics), Molecular Diagnostic Techniques (standards), Point-of-Care Systems (economics), Point-of-Care Systems (standards), Reagent Kits, Diagnostic (economics), Reagent Kits, Diagnostic (standards), Retrospective Studies (MeSH), Sensitivity and Specificity (MeSH), Spain (MeSH), Workflow (MeSH).
MESH :
- chemical , economics : Reagent Kits, Diagnostic.
- geographic : Spain.
- diagnosis : Influenza, Human.
- economics : Clinical Laboratory Techniques, Molecular Diagnostic Techniques, Point-of-Care Systems.
- isolation & purification : Influenza A virus, Influenza B virus.
- standards : Molecular Diagnostic Techniques, Point-of-Care Systems, Reagent Kits, Diagnostic.
- Costs and Cost Analysis, Electronic Health Records, Humans, Retrospective Studies, Sensitivity and Specificity, Workflow.

Abstract

BACKGROUND

Seasonal influenza imposes a considerable burden worldwide. We aimed to evaluate impact of rapid pediatric seasonal influenza diagnosis on laboratory workflow and cost using a rapid antigen detection-based test combined with either a reverse transcriptase polymerase chain reaction (RT-PCR) or the Alere i Influenza A and B (Alere i) assay for confirmation of negative results as well as single Alere i testing on nasopharyngeal aspirates. A secondary objective was assessing performance of Alere i against RT-PCR.

METHODS

Effects of implementing the 3 diagnostic algorithms were assessed in the Emergency Department of Hospital Sant Joan de Déu (Barcelona, Spain) across the 2014-2015, 2015-2016 and 2016-2017 influenza seasons. Alere i performance against RT-PCR was determined during the 2015-2016 epidemic period.

RESULTS

Median time to result decreased when using Alere i as a confirmatory test of previous antigen detection and RT-PCR results or alone (9.7vs. 3.5/2.0 and 0.7 hours, P < 0.001) along with mean testing costs (&OV0556;87.3 vs. &OV0556;38.2 and &OV0556;25.0, P < 0.001). Results available before patient discharge from the emergency department increased from 42.7% for sequential testing by antigen detection and RT-PCR to 80.0% when Alere i was utilized as a stand-alone test. Alere i sensitivity and specificity values were 96.6% (95% confidence interval: 82.8%-99.4%) and 94.4% (95% confidence interval: 86.6%-97.8%), respectively.

CONCLUSIONS

Rapid Alere i testing facilitated efficient laboratory workflow near the patient during influenza epidemics while contributing cost savings when compared with serial testing by antigen and RT-PCR assays.

DOI: 10.1097/INF.0000000000002224
PubMed: 31117115

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 00017
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Le document en format XML

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<author><name sortKey="Launes, Cristian" sort="Launes, Cristian" uniqKey="Launes C" first="Cristian" last="Launes">Cristian Launes</name>
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<country xml:lang="fr">Espagne</country>
<wicri:regionArea>From the Institut de Recerca Sant Joan de Deu, Hospital Sant Joan de Deu</wicri:regionArea>
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</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>Centro de Investigacion Biomedica en Red de Epidemiology y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Spain.</nlm:affiliation>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Centro de Investigacion Biomedica en Red de Epidemiology y Salud Publica (CIBERESP), Instituto de Salud Carlos III</wicri:regionArea>
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<author><name sortKey="Mu Oz Almagro, Carmen" sort="Mu Oz Almagro, Carmen" uniqKey="Mu Oz Almagro C" first="Carmen" last="Mu Oz-Almagro">Carmen Mu Oz-Almagro</name>
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<affiliation wicri:level="1"><nlm:affiliation>Universitat Internacional de Catalunya, Spain.</nlm:affiliation>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Seasonal influenza imposes a considerable burden worldwide. We aimed to evaluate impact of rapid pediatric seasonal influenza diagnosis on laboratory workflow and cost using a rapid antigen detection-based test combined with either a reverse transcriptase polymerase chain reaction (RT-PCR) or the Alere i Influenza A and B (Alere i) assay for confirmation of negative results as well as single Alere i testing on nasopharyngeal aspirates. A secondary objective was assessing performance of Alere i against RT-PCR.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Effects of implementing the 3 diagnostic algorithms were assessed in the Emergency Department of Hospital Sant Joan de Déu (Barcelona, Spain) across the 2014-2015, 2015-2016 and 2016-2017 influenza seasons. Alere i performance against RT-PCR was determined during the 2015-2016 epidemic period.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Median time to result decreased when using Alere i as a confirmatory test of previous antigen detection and RT-PCR results or alone (9.7vs. 3.5/2.0 and 0.7 hours, P < 0.001) along with mean testing costs (&OV0556;87.3 vs. &OV0556;38.2 and &OV0556;25.0, P < 0.001). Results available before patient discharge from the emergency department increased from 42.7% for sequential testing by antigen detection and RT-PCR to 80.0% when Alere i was utilized as a stand-alone test. Alere i sensitivity and specificity values were 96.6% (95% confidence interval: 82.8%-99.4%) and 94.4% (95% confidence interval: 86.6%-97.8%), respectively.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Rapid Alere i testing facilitated efficient laboratory workflow near the patient during influenza epidemics while contributing cost savings when compared with serial testing by antigen and RT-PCR assays.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31117115</PMID>
<DateCompleted><Year>2020</Year>
<Month>04</Month>
<Day>30</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>04</Month>
<Day>30</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1532-0987</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>38</Volume>
<Issue>6</Issue>
<PubDate><Year>2019</Year>
<Month>06</Month>
</PubDate>
</JournalIssue>
<Title>The Pediatric infectious disease journal</Title>
<ISOAbbreviation>Pediatr. Infect. Dis. J.</ISOAbbreviation>
</Journal>
<ArticleTitle>Impact of Rapid On-demand Molecular Diagnosis of Pediatric Seasonal Influenza on Laboratory Workflow and Testing Costs: A Retrospective Study.</ArticleTitle>
<Pagination><MedlinePgn>559-563</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1097/INF.0000000000002224</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Seasonal influenza imposes a considerable burden worldwide. We aimed to evaluate impact of rapid pediatric seasonal influenza diagnosis on laboratory workflow and cost using a rapid antigen detection-based test combined with either a reverse transcriptase polymerase chain reaction (RT-PCR) or the Alere i Influenza A and B (Alere i) assay for confirmation of negative results as well as single Alere i testing on nasopharyngeal aspirates. A secondary objective was assessing performance of Alere i against RT-PCR.</AbstractText>
<AbstractText Label="METHODS">Effects of implementing the 3 diagnostic algorithms were assessed in the Emergency Department of Hospital Sant Joan de Déu (Barcelona, Spain) across the 2014-2015, 2015-2016 and 2016-2017 influenza seasons. Alere i performance against RT-PCR was determined during the 2015-2016 epidemic period.</AbstractText>
<AbstractText Label="RESULTS">Median time to result decreased when using Alere i as a confirmatory test of previous antigen detection and RT-PCR results or alone (9.7vs. 3.5/2.0 and 0.7 hours, P < 0.001) along with mean testing costs (&OV0556;87.3 vs. &OV0556;38.2 and &OV0556;25.0, P < 0.001). Results available before patient discharge from the emergency department increased from 42.7% for sequential testing by antigen detection and RT-PCR to 80.0% when Alere i was utilized as a stand-alone test. Alere i sensitivity and specificity values were 96.6% (95% confidence interval: 82.8%-99.4%) and 94.4% (95% confidence interval: 86.6%-97.8%), respectively.</AbstractText>
<AbstractText Label="CONCLUSIONS">Rapid Alere i testing facilitated efficient laboratory workflow near the patient during influenza epidemics while contributing cost savings when compared with serial testing by antigen and RT-PCR assays.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brotons</LastName>
<ForeName>Pedro</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>From the Institut de Recerca Sant Joan de Deu, Hospital Sant Joan de Deu, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centro de Investigacion Biomedica en Red de Epidemiology y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nogueras</LastName>
<ForeName>Maria-Mercedes</ForeName>
<Initials>MM</Initials>
<AffiliationInfo><Affiliation>From the Institut de Recerca Sant Joan de Deu, Hospital Sant Joan de Deu, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centro de Investigacion Biomedica en Red de Epidemiology y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Valls</LastName>
<ForeName>Ana</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Clinical Laboratory, Hospital Sant Joan de Déu, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Larrauri</LastName>
<ForeName>Amparo</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centro de Investigacion Biomedica en Red de Epidemiology y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centro Nacional de Epidemiología (CNE), Instituto de Salud Carlos III, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dominguez</LastName>
<ForeName>Angela</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Centro de Investigacion Biomedica en Red de Epidemiology y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Departament de Medicina, Universitat de Barcelona, Barcelona, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Launes</LastName>
<ForeName>Cristian</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>From the Institut de Recerca Sant Joan de Deu, Hospital Sant Joan de Deu, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centro de Investigacion Biomedica en Red de Epidemiology y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Luaces-Cubells</LastName>
<ForeName>Carlos</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>Emergency Department, Hospital Sant Joan de Déu, Spain.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Muñoz-Almagro</LastName>
<ForeName>Carmen</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>From the Institut de Recerca Sant Joan de Deu, Hospital Sant Joan de Deu, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Centro de Investigacion Biomedica en Red de Epidemiology y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Spain.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>Universitat Internacional de Catalunya, Spain.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Pediatr Infect Dis J</MedlineTA>
<NlmUniqueID>8701858</NlmUniqueID>
<ISSNLinking>0891-3668</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D011933">Reagent Kits, Diagnostic</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D019411" MajorTopicYN="N">Clinical Laboratory Techniques</DescriptorName>
<QualifierName UI="Q000191" MajorTopicYN="Y">economics</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003365" MajorTopicYN="N">Costs and Cost Analysis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057286" MajorTopicYN="N">Electronic Health Records</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009980" MajorTopicYN="N">Influenza A virus</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009981" MajorTopicYN="N">Influenza B virus</DescriptorName>
<QualifierName UI="Q000302" MajorTopicYN="N">isolation & purification</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D025202" MajorTopicYN="N">Molecular Diagnostic Techniques</DescriptorName>
<QualifierName UI="Q000191" MajorTopicYN="Y">economics</QualifierName>
<QualifierName UI="Q000592" MajorTopicYN="Y">standards</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019095" MajorTopicYN="N">Point-of-Care Systems</DescriptorName>
<QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName>
<QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011933" MajorTopicYN="N">Reagent Kits, Diagnostic</DescriptorName>
<QualifierName UI="Q000191" MajorTopicYN="N">economics</QualifierName>
<QualifierName UI="Q000592" MajorTopicYN="N">standards</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012680" MajorTopicYN="N">Sensitivity and Specificity</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013030" MajorTopicYN="N" Type="Geographic">Spain</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057188" MajorTopicYN="Y">Workflow</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>5</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>5</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>5</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">31117115</ArticleId>
<ArticleId IdType="doi">10.1097/INF.0000000000002224</ArticleId>
<ArticleId IdType="pii">00006454-201906000-00003</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Catalogne</li>
</region>
<settlement><li>Barcelone</li>
</settlement>
<orgName><li>Université de Barcelone</li>
</orgName>
</list>
<tree><country name="Espagne"><noRegion><name sortKey="Brotons, Pedro" sort="Brotons, Pedro" uniqKey="Brotons P" first="Pedro" last="Brotons">Pedro Brotons</name>
</noRegion>
<name sortKey="Brotons, Pedro" sort="Brotons, Pedro" uniqKey="Brotons P" first="Pedro" last="Brotons">Pedro Brotons</name>
<name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Angela" last="Dominguez">Angela Dominguez</name>
<name sortKey="Dominguez, Angela" sort="Dominguez, Angela" uniqKey="Dominguez A" first="Angela" last="Dominguez">Angela Dominguez</name>
<name sortKey="Larrauri, Amparo" sort="Larrauri, Amparo" uniqKey="Larrauri A" first="Amparo" last="Larrauri">Amparo Larrauri</name>
<name sortKey="Larrauri, Amparo" sort="Larrauri, Amparo" uniqKey="Larrauri A" first="Amparo" last="Larrauri">Amparo Larrauri</name>
<name sortKey="Launes, Cristian" sort="Launes, Cristian" uniqKey="Launes C" first="Cristian" last="Launes">Cristian Launes</name>
<name sortKey="Launes, Cristian" sort="Launes, Cristian" uniqKey="Launes C" first="Cristian" last="Launes">Cristian Launes</name>
<name sortKey="Luaces Cubells, Carlos" sort="Luaces Cubells, Carlos" uniqKey="Luaces Cubells C" first="Carlos" last="Luaces-Cubells">Carlos Luaces-Cubells</name>
<name sortKey="Mu Oz Almagro, Carmen" sort="Mu Oz Almagro, Carmen" uniqKey="Mu Oz Almagro C" first="Carmen" last="Mu Oz-Almagro">Carmen Mu Oz-Almagro</name>
<name sortKey="Mu Oz Almagro, Carmen" sort="Mu Oz Almagro, Carmen" uniqKey="Mu Oz Almagro C" first="Carmen" last="Mu Oz-Almagro">Carmen Mu Oz-Almagro</name>
<name sortKey="Mu Oz Almagro, Carmen" sort="Mu Oz Almagro, Carmen" uniqKey="Mu Oz Almagro C" first="Carmen" last="Mu Oz-Almagro">Carmen Mu Oz-Almagro</name>
<name sortKey="Nogueras, Maria Mercedes" sort="Nogueras, Maria Mercedes" uniqKey="Nogueras M" first="Maria-Mercedes" last="Nogueras">Maria-Mercedes Nogueras</name>
<name sortKey="Nogueras, Maria Mercedes" sort="Nogueras, Maria Mercedes" uniqKey="Nogueras M" first="Maria-Mercedes" last="Nogueras">Maria-Mercedes Nogueras</name>
<name sortKey="Valls, Ana" sort="Valls, Ana" uniqKey="Valls A" first="Ana" last="Valls">Ana Valls</name>
</country>
</tree>
</affiliations>
</record>

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Impact of Rapid On-demand Molecular Diagnosis of Pediatric Seasonal Influenza on Laboratory Workflow and Testing Costs: A Retrospective Study.

Impact of Rapid On-demand Molecular Diagnosis of Pediatric Seasonal Influenza on Laboratory Workflow and Testing Costs: A Retrospective Study.

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